Drug discovery and development

Discovery of drug targets and developments of methods to develop, analyze and deliver novel molecules active on specific pathological and microbiological targets

This research scope covers several aspects linked to Drug Development, starting from the high-throughput prediction of molecular targets with computational chemistry and bioinformatics approaches. It further proceeds into synthetic processes by developing novel techniques of pharmaceutical synthesis and extraction from plant matter and microbiological sources.

These drugs are then biochemically tested for their specific effects in appropriate cellular models (e.g. human cell cultures or bacterial populations). Pharmacokinetics and Pharmacodynamics approaches further predict and test for the in vivo behavior of these drugs and for toxic effects.

The final goals of this research scope in our department are both the discovery of new drugs through the full understanding of their mode of action and the development of more efficient ways to develop and synthesize them.

People

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Angela Abruzzo

Senior assistant professor (fixed-term)

keywords: micro and nanocarriers, mucoadhesion, chitosan based drug delivery systems, transdermal and mucosal permeation
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Beatrice Albertini

Associate Professor

keywords: Microencapsulation, Preformulation studies and formulation development, Solvent free process technologies, Solid dosage
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Greta Bagnolini

Research fellow

keywords: Drug Discovery, Organic Chemistry, Medicinal Chemistry, Organic Synthesis, Anticancer Therapies, Protein-Protein
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Monica Baiula

Associate Professor

keywords: Integrin, Drug discovery, Inflammation, Molecular Pharmacology
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Federica Belluti

Associate Professor

keywords: natural products, multititarget drug discovery, design and synthesis of small molecules, antineurodegenetive small

Christian Bergamini

Associate Professor

keywords: Mitochondria, Mitochondrial electron transfer chain, Reactive Oxygen Species, Coenzyme Q10

Federica Bigucci

Associate Professor

keywords: hydrogels, thin films, porous matrices, micro and nanoparticles, mucoadhesion, permeation, modified release
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Alessandra Bisi

Associate Professor

keywords: P-450 Cytochromes, Alzheimer disease, flavonoids, Multidrug resistance
keywords: multitarget drug discovery, design and synthesis, neglected tropical diseases, prion diseases, Alzheimer's disease,
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Francesca Bonvicini

Associate Professor

keywords: antimicrobial compounds, virus-cell interaction, antiviral drugs, microbial biofilms
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Gabriele Campana

Assistant professor

keywords: bile acid, neonatal stress, POMC, FXR, opioids
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Giovanni Capranico

Full Professor

keywords: DNA topoisomerases, R-loop and non-B DNA structures, Non-coding RNAs, Espressione genica, Transcription regulation,
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Marco Caprini

Associate Professor

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Lucia Carboni

Associate Professor

keywords: peripheral biomarkers, Alzheimer's disease, drug discovery, mood disorders, nicotine dependence
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Giacomo Cavalca

PhD Student

keywords: Data science, Artificial intelligence, Machine learning, Deep learning, Bioinformatics
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Teresa Cerchiara

Associate Professor

keywords: hydrogels, natural fibers, cyclodextrin, wound dressings, micro and nanocarriers
keywords: Bioinorganic Chemistry, Biomodelling, Biomolecular NMR spectroscopy, Metallo-chaperons, Urease, X-ray absorption
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Paolo Emidio Costantini

Fixed-term Researcher in Tenure Track L. 79/2022

keywords: Microbiology, Molecular Biology, Phage, Nanoparticle
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Alberto Danielli

Associate Professor

keywords: Phage, Molecular Microbiology, Helicobacter pylori, Nanobiotechnology, theranostic vector
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Eleonora Diamanti

Junior assistant professor (fixed-term)

keywords: Anti-infective agents, Anti microbial resistance problem, PROTAC
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Federico Falchi

Senior assistant professor (fixed-term)

keywords: Molecular Docking, Virtual Screenig, Hit to Lead, SAR, QSAR, 3DQSAR, Protein Protein Interaction, Homology Modelling,
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Giovanna Farruggia

Assistant professor

keywords: fluorescece spectroscopy, flow cytometry, magnesium, fluorescent dye, cell proliferation
keywords: Synthetic lethality, DNA damage repair, SAR studies, Molecule characterization, Pancreatic cancer
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Lucrezia Galassi

PhD Student

Teaching tutor

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Giorgio Gallinella

Full Professor

keywords: Parvovirus B19, Virus-cell interaction, Viral infections, Recombinant virus, Antiviral compounds
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Giovanna Angela Gentilomi

Associate Professor

keywords: ESBL, KPC, Plant extracts, MRSA, Bacterial biofilm
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Silvia Gobbi

Associate Professor

keywords: flavonoids, anticancer drugs, Alzheimer, priviledged structures, hybrid molecules, cytochromes P450, antimicrobics

Roberto Gotti

Associate Professor

keywords: chiral separation, validation of analytical methods, capillary electrophoresis, chromatographic analysis, sample
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Patrizia Hrelia

Full Professor

keywords: Toxicity, Neuroprotection, Chemoprevention, Pharmacogenetic, Preventive medicine, Cancer, Biomarkers
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Stefano Iotti

Full Professor

keywords: fluorescent dyes, Magnesium, Biosensors, hydroxyquinoline derivatives, Synchreotron-based x-ray microscopy, magnetic
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Barbara Luppi

Associate Professor

keywords: transcutaneous and transmucosal permeation, mucoadhesion, hydrogels, modified release, micro e nano carriers, \"health

Emil Malucelli

Associate Professor

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Manuela Mandrone

Associate Professor

keywords: Metabolomics, Phytochemistry, Ethnobotany, Enzyme activity, Nuclear Magnetic Resonance
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Jessica Marinello

Associate Professor

keywords: Human Topoisomerases, R-loops, Non canonical DNA structures, G-quadruplex, DNA damage
keywords: Proteins and RNA structures MD simulations
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Matteo Masetti

Associate Professor

keywords: Drug discovery and development, Molecular Dynamics simulations, Free energy calculations, Potassium channels
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Andrea Maurizio

PhD Student

Teaching tutor

keywords: Integrins, Molecular and Cellular Pharmacology, Drug Discovery, Inflammation, Cancer
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Luca Mazzei

Fixed-term Researcher in Tenure Track L. 79/2022

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Laura Mercolini

Associate Professor

keywords: Drugs of abuse, Anti-doping analysis, Therapeutic drug monitoring (TDM), Analysis of natural compounds, Liquid
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Viviana Mitarotonda

PhD Student

Teaching tutor

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Barbara Monti

Full Professor

keywords: neurodevelopmental disorders, AGC1-deficiency, Angelman syndrome, neurodegenerative diseases, Alzheimer's disease,
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Fabiana Morroni

Associate Professor

keywords: Alzheimer's disease, Bioactive compounds, Neuroprotection, Parkinson's disease, Neurodegeneration
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Francesco Musiani

Associate Professor

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Marina Naldi

Associate Professor

keywords: Mass spectrometry; Liquid chromatography; Protein characterization; Post-translational modification; Surface plasmon
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Moreno Paolini

Full Professor

keywords: Chemoprevention, Cocancerogenesis, Free radicals, Phytochemicals, Cytochrome P450

Carola Eleonora Parolin

Senior assistant professor (fixed-term)

keywords: human microbiota, vaginal ecosystem, Lactobacillus, probiotics
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Nadia Passerini

Full Professor

keywords: drug delivery, solid dosage forms, formulation of paediatric medicines, physicochemical properties of solid dosage
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Ferruccio Poli

Full Professor

keywords: medicinal plants, metabolomics,, ethnobotany, phytochemistry, biological activities, smart agriculture, Quality
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Laura Poppi

PhD Student

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Michele Protti

Senior assistant professor (fixed-term)

keywords: Analytical methods, Microsampling, Sample pretreatment, doping agents, Drugs of abuse, SNC drugs, Biological and
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Marinella Roberti

Associate Professor

keywords: cancer, parallel synthesis, chemical biology, small molecules, cystic fibrosis
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Patrizia Romualdi

Full Professor

keywords: gene expression, neuropeptides, opioid peptides, neurodegeneration, addictive drugs
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Davide Roncarati

Associate Professor

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Vincenzo Scarlato

Full Professor

keywords: Transcriptome, Protein-DNA Interactions, Transcriptional regulation, Functional genomics, Drug discovery
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Giusy Tespio

PhD Student

keywords: liquid chromatography, mass spectrometry, analytical method development, sample stability, microsampling, banned
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Roberto Tonelli

Assistant professor

keywords: Pharmaceutical Biotechnology, Preclinical Molecular Pharmacology, Oncology
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Elisa Uliassi

Senior assistant professor (fixed-term)

keywords: polypharmacology, multi-target-directed-ligand, neurodegenerative diseases, neglected tropical diseases
keywords: Molecular dynamics
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Beatrice Vitali

Associate Professor

keywords: human microbiota, probiotic bacteria, molecular culture-independent techniques, Lactobacillus
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Suleman Khan Zadran

Research fellow

keywords: Molecular biotechnology of phages- Development of theranostic vectors- Gene expression regulation in cancer- Molecular
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Barbara Zambelli

Associate Professor

keywords: intrinsically disordered proteins, metal-homeostasis, urease, nickel, protein-protein interactions