Drug discovery and development

Discovery of drug targets and developments of methods to develop, analyze and deliver novel molecules active on specific pathological and microbiological targets

This research scope covers several aspects linked to Drug Development, starting from the high-throughput prediction of molecular targets with computational chemistry and bioinformatics approaches. It further proceeds into synthetic processes by developing novel techniques of pharmaceutical synthesis and extraction from plant matter and microbiological sources.

These drugs are then biochemically tested for their specific effects in appropriate cellular models (e.g. human cell cultures or bacterial populations). Pharmacokinetics and Pharmacodynamics approaches further predict and test for the in vivo behavior of these drugs and for toxic effects.

The final goals of this research scope in our department are both the discovery of new drugs through the full understanding of their mode of action and the development of more efficient ways to develop and synthesize them.

People

Angela Abruzzo

Junior assistant professor (fixed-term)

keywords: micro and nanocarriers, mucoadhesion, chitosan based drug delivery systems, transdermal and mucosal permeation
foto della persona

Beatrice Albertini

Associate Professor

keywords: Microencapsulation, Preformulation studies and formulation development, Solvent free process technologies, Solid dosage

Federico Antoniciello

PhD Student

Teaching tutor

foto della persona

Monica Baiula

Senior assistant professor (fixed-term)

D cat. - technical, scientific and data processing area

keywords: Integrin, Drug discovery, Inflammation, Molecular Pharmacology
foto della persona

Federica Belluti

Associate Professor

keywords: natural products, multititarget drug discovery, design and synthesis of small molecules, antineurodegenetive small

Christian Bergamini

Associate Professor

keywords: Mitochondria, Mitochondrial electron transfer chain, Reactive Oxygen Species, Coenzyme Q10
foto della persona

Serena Bertoni

Research fellow

Teaching tutor

keywords: Microencapsulation, Modified release drug delivery systems, Solid state characterization, Oral formulations

Federica Bigucci

Associate Professor

keywords: hydrogels, polymeric films, freeze dried matrices, particulate systems, mucoadhesion, permeation
foto della persona

Alessandra Bisi

Associate Professor

keywords: P-450 Cytochromes, Alzheimer disease, flavonoids, Multidrug resistance
keywords: multitarget drug discovery, design and synthesis, neglected tropical diseases, prion diseases, Alzheimer's disease,
foto della persona

Francesca Bonvicini

Associate Professor

keywords: viral infections, antiviral drugs, virus-cell interaction, antimicrobial compounds
foto della persona

Gabriele Campana

Assistant professor

keywords: bile acid, neonatal stress, POMC, FXR, opioids
foto della persona

Giovanni Capranico

Full Professor

keywords: DNA topoisomerases, R-loop and non-B DNA structures, Non-coding RNAs, Espressione genica, Transcription regulation,
foto della persona

Marco Caprini

Associate Professor

foto della persona

Lucia Carboni

Associate Professor

keywords: peripheral biomarkers, Alzheimer's disease, drug discovery, mood disorders, nicotine dependence
foto della persona

Teresa Cerchiara

Associate Professor

keywords: hydrogels, natural fibers, cyclodextrin, wound dressings
foto della persona

Marco Cirrincione

PhD Student

Teaching tutor

keywords: microsampling, miniaturised pretreatment, liquid chromatography, mass spectrometry, drugs of abuse
keywords: Bioinorganic Chemistry, Biomodelling, Biomolecular NMR spectroscopy, Metallo-chaperons, Urease, X-ray absorption
foto della persona

Paolo Emidio Costantini

Research fellow

Teaching tutor

foto della persona

Alberto Danielli

Associate Professor

keywords: Phage, Molecular Microbiology, Helicobacter pylori, Nanobiotechnology, theranostic vector
foto della persona

Federico Falchi

Senior assistant professor (fixed-term)

keywords: Molecular Docking, Virtual Screenig, Hit to Lead, SAR, QSAR, 3DQSAR, Protein Protein Interaction, Homology Modelling,
foto della persona

Giovanna Farruggia

Assistant professor

keywords: fluorescece spectroscopy, flow cytometry, magnesium, fluorescent dye, cell proliferation
foto della persona

Giorgio Gallinella

Full Professor

keywords: Parvovirus B19, Virus-cell interaction, Viral infections, Recombinant virus, Antiviral compounds
foto della persona

Giovanna Angela Gentilomi

Associate Professor

keywords: ESBL, KPC, Plant extracts, MRSA, Bacterial biofilm
foto della persona

Silvia Gobbi

Associate Professor

Roberto Gotti

Associate Professor

keywords: chiral separation , validation of analytical methods , capillary electrophoresis, chromatographic analysis, sample
foto della persona

Patrizia Hrelia

Full Professor

keywords: Toxicity, Neuroprotection, Chemoprevention, Pharmacogenetic, Preventive medicine, Cancer, Biomarkers
foto della persona

Stefano Iotti

Full Professor

keywords: fluorescent dyes, Magnesium, Biosensors, hydroxyquinoline derivatives, Synchreotron-based x-ray microscopy, magnetic
foto della persona

Alberto Leoni

Associate Professor

keywords: Study of the structure-activity relationships, Study of the mechanism of action, Evaluation of the antitumor activity,
foto della persona

Barbara Luppi

Associate Professor

keywords: transcutaneous and transmucosal permeation, mucoadhesion, hydrogels, modified release, micro e nano carriers, \"health

Emil Malucelli

Associate Professor

foto della persona

Manuela Mandrone

Senior assistant professor (fixed-term)

keywords: Metabolomics, Phytochemistry, Ethnobotany, Enzyme activity, Nuclear Magnetic Resonance

Jessica Marinello

Senior assistant professor (fixed-term)

keywords: Human Topoisomerases, R-loops, Non canonical DNA structures, G-quadruplex, DNA damage

Marco Maronese

PhD Student

foto della persona

Matteo Masetti

Associate Professor

keywords: Drug discovery and development, Molecular Dynamics simulations, Free energy calculations, Potassium channels
foto della persona

Luca Mazzei

Junior assistant professor (fixed-term)

foto della persona

Daniele Mercatelli

Junior assistant professor (fixed-term)

keywords: Bioinformatics, Transcriptomics, Gene Networks, Genomics, Oncology, Biostatistics, Radiomics
foto della persona

Laura Mercolini

Associate Professor

keywords: Drugs of abuse, Anti-doping analysis, Therapeutic drug monitoring (TDM), Analysis of natural compounds, Liquid
foto della persona

Fabiana Morroni

Associate Professor

keywords: Alzheimer's disease, Bioactive compounds, Neuroprotection, Parkinson's disease, Neurodegeneration
foto della persona

Francesco Musiani

Associate Professor

foto della persona

Marina Naldi

Senior assistant professor (fixed-term)

keywords: Mass spectrometry; Liquid chromatography; Protein characterization; Post-translational modification; Surface plasmon
foto della persona

Moreno Paolini

Full Professor

keywords: Chemoprevention, Cocancerogenesis, Free radicals, Phytochemicals, Cytochrome P450

Carola Eleonora Parolin

Junior assistant professor (fixed-term)

keywords: human microbiota, vaginal ecosystem, Lactobacillus, probiotics
foto della persona

Nadia Passerini

Full Professor

keywords: drug delivery, solid dosage forms, formulation of paediatric medicines, physicochemical properties of solid dosage
foto della persona

Ferruccio Poli

Full Professor

keywords: medicinal plants, metabolomics,, ethnobotany, phytochemistry, biological activities, smart agriculture, Quality
foto della persona

Michele Protti

Junior assistant professor (fixed-term)

keywords: Analytical methods, Microsampling, Sample pretreatment, doping agents, Drugs of abuse, SNC drugs, Biological and
foto della persona

Francesco Rinaldi

PhD Student

Teaching tutor

keywords: RAD51, BRCA2, BRC4
foto della persona

Marinella Roberti

Associate Professor

keywords: cancer, parallel synthesis, chemical biology, small molecules, cystic fibrosis

Patrizia Romualdi

Associate Professor

keywords: gene expression, neuropeptides, opioid peptides, neurodegeneration, addictive drugs
foto della persona

Davide Roncarati

Associate Professor

foto della persona

Stefano Sangiorgi

PhD Student

Teaching tutor

foto della persona

Vincenzo Scarlato

Full Professor

keywords: Transcriptome, Protein-DNA Interactions, Transcriptional regulation, Functional genomics, Drug discovery
foto della persona

Giusy Tespio

PhD Student

keywords: liquid chromatography, mass spectrometry, analytical method development, sample stability, microsampling, banned
foto della persona

Roberto Tonelli

Assistant professor

keywords: Pharmaceutical Biotechnology, Preclinical Molecular Pharmacology, Oncology
foto della persona

Elisa Uliassi

Junior assistant professor (fixed-term)

keywords: polypharmacology, multi-target-directed-ligand, neurodegenerative diseases, neglected tropical diseases
keywords: Molecular dynamics
foto della persona

Beatrice Vitali

Associate Professor

keywords: human microbiota, probiotic bacteria, molecular culture-independent techniques, Lactobacillus
keywords: Molecular biotechnology of phages- Development of theranostic vectors- Gene expression regulation in cancer- Molecular
foto della persona

Barbara Zambelli

Associate Professor

keywords: intrinsically disordered proteins, metal-homeostasis, urease, nickel, protein-protein interactions