Drug discovery and development

Discovery of drug targets and developments of methods to develop, analyze and deliver novel molecules active on specific pathological and microbiological targets

This research scope covers several aspects linked to Drug Development, starting from the high-throughput prediction of molecular targets with computational chemistry and bioinformatics approaches. It further proceeds into synthetic processes by developing novel techniques of pharmaceutical synthesis and extraction from plant matter and microbiological sources.

These drugs are then biochemically tested for their specific effects in appropriate cellular models (e.g. human cell cultures or bacterial populations). Pharmacokinetics and Pharmacodynamics approaches further predict and test for the in vivo behavior of these drugs and for toxic effects.

The final goals of this research scope in our department are both the discovery of new drugs through the full understanding of their mode of action and the development of more efficient ways to develop and synthesize them.

People

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Beatrice Albertini

Associate Professor

keywords: Microencapsulation, Preformulation studies and formulation development, Solvent free process technologies, Solid dosage
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Monica Baiula

Junior assistant professor (fixed-term)

D cat. - technical, scientific and data processing area

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Federica Belluti

Associate Professor

keywords: natural products, multititarget drug discovery, design and synthesis of small molecules, antineurodegenetive small

Christian Bergamini

Associate Professor

keywords: Mitochondria, Mitochondrial electron transfer chain, Reactive Oxygen Species, Coenzyme Q10
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Alessandra Bisi

Associate Professor

keywords: P-450 Cytochromes, Alzheimer disease, flavonoids, Multidrug resistance
keywords: multitarget drug discovery, design and synthesis, neglected tropical diseases, prion diseases, Alzheimer's disease,
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Francesca Bonvicini

Assistant professor

keywords: viral infections, antiviral drugs, virus-cell interaction, antimicrobial compounds

Irene Brusa

PhD Student

Research fellow

Teaching tutor

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Gabriele Campana

Assistant professor

keywords: bile acid, neonatal stress, POMC, FXR, opioids
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Lucia Carboni

Assistant professor

keywords: peripheral biomarkers, Alzheimer's disease, drug discovery, mood disorders, nicotine dependence
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Marco Cirrincione

PhD Student

Teaching tutor

keywords: microsampling, miniaturised pretreatment, liquid chromatography, mass spectrometry, drugs of abuse
keywords: Bioinorganic Chemistry, Biomodelling, Biomolecular NMR spectroscopy, Metallo-chaperons, Urease, X-ray absorption
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Paolo Emidio Costantini

Research fellow

Teaching tutor

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Alberto Danielli

Associate Professor

keywords: Phage, Molecular Microbiology, Helicobacter pylori, Nanobiotechnology, theranostic vector
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Giovanna Farruggia

Assistant professor

keywords: fluorescece spectroscopy, flow cytometry, magnesium, fluorescent dye, cell proliferation
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Giorgio Gallinella

Full Professor

keywords: Parvovirus B19, Virus-cell interaction, Viral infections, Recombinant virus, Antiviral compounds
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Giovanna Angela Gentilomi

Associate Professor

keywords: ESBL, KPC, Plant extracts, MRSA
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Silvia Gobbi

Associate Professor

Roberto Gotti

Associate Professor

keywords: chiral separation , validation of analytical methods , capillary electrophoresis, chromatographic analysis, sample
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Patrizia Hrelia

Full Professor

keywords: Toxicity, Neuroprotection, Chemoprevention, Pharmacogenetic, Preventive medicine, Cancer, Biomarkers
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Stefano Iotti

Full Professor

keywords: fluorescent dyes, Magnesium, Biosensors, hydroxyquinoline derivatives, Synchreotron-based x-ray microscopy, magnetic

Alberto Leoni

Associate Professor

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Barbara Luppi

Associate Professor

keywords: transcutaneous and transmucosal permeation, mucoadhesion, hydrogels, modified release, micro e nano carriers, \"health

Emil Malucelli

Associate Professor

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Daniele Mercatelli

Research fellow

Teaching tutor

keywords: Bioinformatics, Transcriptomics, Gene Networks, Genomics, Oncology, Biostatistics, Radiomics
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Laura Mercolini

Associate Professor

keywords: Drugs of abuse, Anti-doping analysis, Therapeutic drug monitoring (TDM), Analysis of natural compounds, Liquid
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Francesco Musiani

Associate Professor

Marina Naldi

Senior assistant professor (fixed-term)

keywords: Mass spectrometry; Liquid chromatography; Protein characterization; Post-translational modification; Surface plasmon
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Nadia Passerini

Associate Professor

keywords: drug delivery, solid dosage forms, formulation of paediatric medicines, physicochemical properties of solid dosage
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Ferruccio Poli

Full Professor

keywords: medicinal plants, metabolomics,, ethnobotany, phytochemistry, biological activities, smart agriculture, Quality

Angela Rampa

Alma Mater Honorary Professor

Adjunct professor

keywords: Aromatasi, MDR
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Alessandro Reggiani

PhD Student

Teaching tutor

keywords: Parvovirus B19, Viral infections, Antiviral compounds
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Francesco Rinaldi

PhD Student

Teaching tutor

keywords: RAD51, BRCA2, BRC4
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Marinella Roberti

Associate Professor

keywords: cancer, parallel synthesis, chemical biology, small molecules, cystic fibrosis
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Stefano Sangiorgi

Research fellow

Teaching tutor

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Roberto Tonelli

Assistant professor

keywords: Pharmaceutical Biotechnology, Preclinical Molecular Pharmacology, Oncology
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Elisa Uliassi

Junior assistant professor (fixed-term)

keywords: polypharmacology, multi-target-directed-ligand, neurodegenerative diseases, neglected tropical diseases
keywords: Molecular biotechnology of phages- Development of theranostic vectors- Gene expression regulation in cancer- Molecular
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Barbara Zambelli

Assistant professor

keywords: intrinsically disordered proteins, metal-homeostasis, urease, nickel, protein-protein interactions
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