Research themes
Research Themes
The research activity of the group focuses on the design and synthesis of multifunctional ligands and electrophilic covalent probes in the study of targets and biological pathways involved in neurodegeneration and cancer. In particular, the research lines cover the development of:
- antioxidant/antinflammatory molecules
- Aβ peptide antiaggregating molecule
- Protein-kinase GSK3-beta and Fyn inhibitors
- NMDA receptor antagonists
- Polyamine derivatives with anticancer activity
- amino oxidase inhibitors
The group has a documented expertise in the structural modification of natural compounds, quinazoline derivatives and aromatic heterocycles, and in the synthesis of polyamine conjugated of bioactive molecules to improve the cellular and subcellular cellular delivery.