Internship projects
Every year the research group can guest 4 students for the preparation of the experimental thesis that takes place in about 8 months and, every three years, a position for the PhD program. The thesis work consists in the synthesis, purification and characterization of organic molecules designed on the basis of ongoing research projects in the group.
Main publications
Basagni F, Lanni C, Minarini A, Rosini M. Lights and shadows of electrophile signaling: focus on the Nrf2-Keap1 pathway. Future Med, Chem., 2019, 11, 707-721. 10.4155/fmc-2018-0423
Simoni E, Serafini MM, Caporaso R, Marchetti C, Racchi M, Minarini A, Bartolini B, Lanni C, Rosini M. Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach. ACS Chem. Neurosci., 2017, 8, 1618-1627. 10.1021/acschemneuro.7b00100
Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini B, Rosini M. Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease. ACS Med. Chem. Lett., 2016, 7, 1145–1150. 10.1021/acsmedchemlett.6b00339
Palermo G, Minniti E, Greco ML, Riccardi L, Simoni E, Convertino M, Marchetti C, Rosini M, Sissi C, Minarini A, De Vivo M. An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512. Chem. Commun., 2015, 51, 14310-14313. 2015/cc/c5cc05065k
Rosini M, Simoni E, Milelli A, Minarini A, Melchiorre C. Oxidative stress in Alzheimer’s disease: are we connecting the dots? J. Med. Chem. 2014, 57, 2821-2831. 10.1021/jm400970m