Pharmaco-Toxicological Analysis (PTA Lab). Coordinator: Mercolini

Development of advanced strategies for the instrumental analysis of active compounds in complex matrices by liquid chromatography and capillary electrophoresis coupled to different types of detection. Focus on innovative miniaturized sampling and pretreatment procedures for biological and non-biological samples

Research themes

  • Development and validation of microsampling and miniaturised pretreatment procedures for biological and non-biological samples, e.g., by means of VAMS, DMS, MEPS, µ-SPE, SPME, LLME.
  • Design of advanced analytical approaches based on 3D printing and lab-on-chip platforms featuring high-throughput for the point-of-care analysis. 
  • The instrumental techniques used are high performance liquid chromatography (HPLC, UHPLC) and capillary electrophoresis (CE), coupled to the main detection means: mass spectrometry, electrochemical, spectrofluorimetry, spectrophotometry.

Lab members

Laura Mercolini

Associate Professor of Medicinal Chemistry (CHIM/08)

Head of the Research Group of Pharmaco-Toxicological Analysis (PTA Lab)

Director of the II level Professional Master in Forensic Chemical and Chemical-Toxicological Analyses 

(website of the Professional Master

Michele Protti

Junior Assistant Professor of Medicinal Chemistry (CHIM/08)

Camilla Marasca

Ph.D. Student in Biotechnological, Biocomputational, Pharmaceutical and Pharmacological Science

Marco Cirrincione

Ph.D. Student in Health, Safety and Green Systems

Giusy Tespio 

Ph.D. Student, Health, Safety and Green Systems 

Internship projects

Experimental activities aimed at thesis dissertation in Chemistry and Pharmaceutical Technologies, Pharmacy, Applied Pharmaceutical Sciences, Health Biology and within the II level Professional Master in Forensic Chemical and Chemical-Toxicological Analyses.

Main publications

Cirrincione M, Saladini B, Brighenti V, Salamone S, Mandrioli R, Pollastro F, Pellati F, Protti M, Mercolini L. Discriminating different Cannabis sativa L. chemotypes using attenuated total reflectance - infrared (ATR-FTIR) spectroscopy: A proof of conceptJ. Pharm. Biomed. Anal. 2021 Sep 204 (2021) 114270. DOI: 10.1016/j.jpba.2021.114270. 

Protti M., Marasca C., Cirrincione M., Cavalli A., Mandrioli R., Mercolini L. Assessment of capillary volumetric blood microsampling for the analysis of central nervous system drugs and metabolitesAnalyst. 145, 5744-5753, 2020. DOI: 10.1039/d0an01039a 

Protti M., Mandrioli R., Mercolini L. Tutorial: Volumetric absorptive microsampling (VAMS) Analytica Chimica Acta 1046, 32-47, 2019. DOI: 10.1016/j.aca.2018.09.004

Protti M., Marasca C., Cirrincione M., Cavalli A., Mandrioli R., Mercolini L. Assessment of capillary volumetric blood microsampling for the analysis of central nervous system drugs and metabolites. Analyst. 145, 5744-5753, 2020. DOI: 10.1039/d0an01039a

Protti M., Mandrioli R., Mercolini L. Tutorial: Volumetric absorptive microsampling (VAMS). Analytica Chimica Acta 1046, 32-47, 2019. DOI: 10.1016/j.aca.2018.09.004

Contacts