Research themes
Research involves the design and synthesis of bioactive small molecules as potential drug candidates. Scaffolds are mainly oxa- and azaheterocycles, related to different classes of natural products. These molecules can be considered as privileged structures and carriers that, when differently functionalized with appropriate pharmacophore moieties, can tailor the activity towards one or more targets involved in complex pathologies.
Main research themes are related to the development of molecules able to modulate the activities of:
- targets involved in the development of neurodegenerative disorders such as cholinesterases, kinases, FAAH and cannabinoids receptors, trascription factor Nrf-2
- cytochromes P450 involved in the biosynthesis of estrogens and of estrogen receptors as antitumor agents
- enzymes involved in tumor progression and multiple drug resistance (MDR)
- key enzymes for the development of tropical parasitic diseases such as malaria, leishmanial infections and trypanosomiasis