Internship projects
Internship for the preparation of a degree thesis has a duration of more or less 8 months and involves the synthesis, purification and structural characterization of bioactive small molecules. The student takes part in one of the ongoing projects of the research group, in particular neurodegeneration, tumor or parasitic neglected diseases. 4/6 positions are available per year.
Main publications
Caciolla, J.; Martini, S.; Spinello, A.; Pavlin, M.; Turrini, E.; Simonelli, F.; Belluti, F.; Rampa, A.; Bisi, A.; Fimognari, C.; Zaffaroni, N.; Gobbi, S.; Magistrato, A. Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer. Eur. J. Med. Chem. (2021), 224, 113733 doi: 10.1016/j.ejmech.2021.113733.
Caciolla, J.; Picone, G.; Farruggia, G.; Valenti, D.; Rampa, A.; Malucelli, E.; Belluti, F.; Trezza, A.; Spiga, O.; Iotti, S.; Gobbi, S.; Cappadone, C.; Bisi, A. Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer. Bioorg Chem. (2021) 106, 104460. doi: 10.1016/j.bioorg.2020.104460.
Di Martino, R.M.C.; Pruccoli, L.; Bisi, A.; Gobbi, S.; Rampa, A.; Martinez, A.; Pérez, C.; Martinez-Gonzalez, L.; Paglione, M.; Di Schiavi, E.; Seghetti, F.; Tarozzi, A.; Belluti, F. Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease. ACS Chem Neurosci. (2020, 11, 2728-2740. doi: 10.1021/acschemneuro.0c00363.
Bonvicini, F.; Manet, I.; Belluti, F.; Gobbi, S.; Rampa, A.; Gentilomi, G.A.; Bisi, A. Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections. ACS Infect Dis. (2019), 5, 1524-1534. doi: 10.1021/acsinfecdis.9b00072.
Ortalli, M.; Ilari, A.; Colotti, G.; De Ionna, I.; Battista, T.; Bisi, A.; Gobbi, S.; Rampa, A.; Di Martino, R. M. C.; Gentilomi, G.A.; Varani, S.; Belluti, F. Identification of chalcone-based antileishmanial agents targeting trypanothione reductase. Eur. J. Med. Chem. (2018), 152, 527-541. doi: 10.1016/j.ejmech.2018.04.057