Internship projects
Internship projects (6) concern the development of research themes.
Main publications
Amato J, Morigi R., Pagano B., Pagano A., Ohnmacht S., De Magis A., Tiang Y-P., Capranico G., Locatelli A., Graziadio A., Leoni A., Rambaldi M., Novellino E., Neidle S., Randazzo A. “Toward the Development of Specific G‑Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.” J. Med. Chem. 59: 5706-5720 (2016).
Morigi R, Locatelli A, Leoni A, Rambaldi M, Bortolozzi R, Mattiuzzo E, Ronca R, Maccarinelli F, Hamel E, Bai R, Brancale A, Viola G.: Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents. Eur.J.Med.Chem. 166, 514-530 (2019).
Conti I, Morigi R, Locatelli A, Rambaldi M, Bua G, Gallinella G, Leoni A.: Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one derivatives and study of their antiviral activity against parvovirus B19. Molecules 24 (6), 1-15 (2019).
Locatelli A, Iommarini L, Graziadio A, Leoni A, Porcelli A.M, Iotti S, Malucelli E, Francia F, Venturoli G, Farruggia G.: Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose. RSC Advances 9, 15350-15356 (2019).
Amato J, Miglietta G, Morigi R, Iaccarino N, Locatelli A, Leoni A, Novellino E, Pagano B, Capranico G, Randazzo A. (2020) “Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells” J Med Chem. 63(6): 3090-3103. DOI: 10.1021/acs.jmedchem.9b01866