Beneficial Microbes - Coordinator: Beatrice Vitali

Molecular and functional characterization of human microbiota and probiotic microorganisms. Study of the interactions between mutualistic bacteria, pathogens and host.

Research themes

  • Characterization of human microbial ecosystems. Phylogenetic analysis using molecular techniques based on the 16S rRNA gene, and functional analysis by means of metabolomic and proteomic approaches. Study of the interactions between mutualistic bacteria, pathogens and cellular epithelium of the host.
  • Study of the health-promoting effects of probiotic bacteria. Study of the molecular mechanisms underlying the therapeutic activities of probiotic bacteria: production of antimicrobial metabolites, ability to form biofilms, modulation of cellular epithelial membrane functions, interaction with the immune system.
  • Selection/characterization of bacterial strains and metabolites/derivatives for the development of probiotic formulations. New health-promoting strains, belonging to the genera Lactobacillus and Bifidobacterium, and their metabolites/derivatives are characterized in terms of antimicrobial activities, interactions with epithelial tissues, compatibility with the biological fluids and with technological processes used for their formulation.

Lab members

Carola Parolin, Ricercatrice a Tempo Determinato di tipo A (sito web di C.P.);

Barbara Giordani, Assegnista di Ricerca PostDoc (sito web di B.G.);

Vanessa Croatti, (sito web di V.C. ).

Job openings or internship projects 

Internship positions are available for the above-mentioned research topics.

 

Main publications

  • Parolin, C., Croatti, V., Laghi, L., Giordani, B., Tondi, M. R., De Gregorio, P. R, Foschi, C., Vitali, B. (2021) “Lactobacillus biofilms influence anti-Candida” Frontiers in Microbiology 12: 750368. https://doi.org/10.3389/fmicb.2021.750368.
  • Costantini, P. E., Firrincieli, A., Fedi, S., Parolin, C., Viti, C., Cappelletti, M., Vitali, B. (2021). “Insight into phenotypic and genotypic differences between vaginal Lactobacillus crispatus BC5 and Lactobacillus gasseri BC12 to unravel nutritional and stress factors influencing their metabolic activity.” Microbial Genomics 7(6): 2057-5858. https://doi.org/10.1099/mgen.0.000575.
  • Parolin, C., Abruzzo, A., Giordani, B., Oliver, J. C., Marangoni, A., Luppi, B., Vitali, B. (2021). “Anti-Candida activity of hyaluronic acid combined with Lactobacillus crispatus lyophilised supernatant: a new antifungal strategy.” Antibiotics 10(6): 628. https://doi.org/10.3390/antibiotics10060628.
  • De Gregorio, P. R., Parolin, C., Abruzzo, A., Luppi, B., Protti, M., Mercolini, L., Silva, J. A., Giordani, B., Marangoni, A., Nader-Macías, M. E. F., Vitali, B. (2020). “Biosurfactant from vaginal Lactobacillus crispatus BC1 as a promising agent to interfere with Candida” Microbial Cell Factories 19: 1475-2859. https://doi.org/10.1186/s12934-020-01390-5.
  • Ñahui Palomino, R. A, Vanpouille, C., Laghi, L., Parolin, C., Melikov, K., Backlund, P., Vitali, B., Margolis. (2019). “Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues.” Nature Communications 10: 5656. https://doi.org/10.1038/s41467-019-13468-9.

 

 

 

Contacts