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Department of Pharmacy and Biotechnology - FABIT

Microbiology and Clinical Microbiology. Coordinator: Gallinella

Study of viruses and microorganisms of medical interest, in their biological characteristics and ability to interact with the human host, the development of innovative diagnostic technologies for the diagnosis of infectious processes and the search for new compounds with antiviral and antimicrobial activity.

Areas: Drug discovery and development

Research themes

In the virological field, the research group deals with: development of techniques for the research of nucleic acids and viral antigens in biological samples; Development of point-of-care miniature assays and devices for the diagnosis of viral infection; Reverse genetics techniques for the production of recombinant viruses; Molecular cloning techniques for the expression of heterologous proteins in prokaryotic and eukaryotic systems. In particular, the study of parvovirus B19 is a major theme in various aspects: functional analysis and expression profile of parvovirus B19 genome; Evaluation of antiviral activity of compounds against parvovirus B19; Diagnosis and characterization of different pathogenetic and clinical aspects of parvovirus B19 infection.

In the field of microbiology (Referent: Giovanna Angela Gentilomi), the research topics concern the evaluation of the antibacterial and antifungal activity of inorganic, polymeric and composite materials, synthesis and plant formulations with particular attention to the identification of active compounds against resistant multi-drug bacteria (MDRs).

Lab Members

Giorgio Gallinella, Full Professor

Giovanna Angela Gentilomi,  Associate Professor

Elisabetta Manaresi, Senior Assistant Professor

Francesca Bonvicini,  Associate Professor

Gloria Bua , Research Fellow

Erika Fasano, PhD Student

Main publications

- Advances in the Development of Antiviral Strategies against Parvovirus B19. Manaresi E, Gallinella G. Viruses. 2019 Jul 18;11(7):659. doi: 10.3390/v11070659. PMID: 31323869

- Antiviral activity of brincidofovir on parvovirus B19. Bua G, Conti I, Manaresi E, Sethna P, Foster S, Bonvicini F, Gallinella G. Antiviral Res. 2019 Feb;162:22-29. doi: 10.1016/j.antiviral.2018.12.003. Epub 2018 Dec 8. PMID: 30529090

- A Parvovirus B19 synthetic genome: sequence features and functional competence. Manaresi E, Conti I, Bua G, Bonvicini F, Gallinella G. Virology. 2017. doi: 10.1016/j.virol.2017.05.006.

- Parvovirus B19 Replication and Expression in Differentiating Erythroid Progenitor Cells. Bua G, Manaresi E, Bonvicini F, Gallinella G. PLoS One. 2016. doi: 10.1371/journal.pone.0148547.

- Monocyclic β-lactams loaded on hydroxyapatite: new biomaterials with enhanced antibacterial activity against resistant strains. Giacomini D, Torricelli P, Gentilomi GA, Boanini E, Gazzano M, Bonvicini F, Benetti E, Soldati R, Martelli G, Rubini K, Bigi A. Scientific Reports (2017) doi:10.1038/s41598-017-02943-2.

 

Contacts