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Department of Pharmacy and Biotechnology - FABIT

Molecular Biotechnology Lab (MBT). Coordinator: Danielli

Development of innovative nanomedicines and biosensors based on filamentous phages and self-assembling bionanoparticles.

Areas: Drug discovery and development Industrial, plant and environmental biotechnologies Nutrition and health
Engineered phage (red) targeting epidermoid cancer cells

Research themes

  1. Engineering of phage-based targeting vectors for innovative therapeutics
  2. Phage biosensors
  3. Phage- and NP-based supplements for human and veterinary health-care

https://site.unibo.it/molecular-biotechnology-lab/en

 

Lab members

Alberto Danielli, Associate Professor (e-mail)

Paolo Emidio Costantini, Post-doctoral Researcher

Annapaola Petrosino, PhD Student

Luca Ulfo, PhD Student

Suleman Khan Zadran, PhD Student (co-tutor Prof. G.Perini)

Tommaso Rossi, PhD Student

Lucia Pappagallo, PhD Student

Alena Kaltenbrunner, PhD Student

Internship projects

Contact the group leader

Main publications

  • Ulfo L, Cantelli A, Petrosino A, Costantini PE, Nigro M, Starinieri F, Turrini E, Zadran SK, Zuccheri G, Saporetti R, Di Giosia M, Danielli A, Calvaresi M. Orthogonal nanoarchitectonics of M13 phage for receptor targeted anticancer photodynamic therapy. Nanoscale. 2022 Jan 20;14(3):632-641. doi: 10.1039/d1nr06053h.
  • Ulfo L, Costantini PE, Di Giosia M, Danielli A, Calvaresi M. EGFR-Targeted Photodynamic Therapy. Pharmaceutics. 2022 Jan 20;14(2):241. doi: 10.3390/pharmaceutics14020241.
  • Bortot B, Apollonio M, Baj G, Andolfi L, Zupin L, Crovella S, di Giosia M, Cantelli A, Saporetti R, Ulfo L, Petrosino A, Di Lorenzo G, Romano F, Ricci G, Mongiat M, Danielli A, Calvaresi M, Biffi S. Advanced photodynamic therapy with an engineered M13 phage targeting EGFR: Mitochondrial localization and autophagy induction in ovarian cancer cell lines. Free Radic Biol Med. 2022 Feb 1;179:242-251. doi: 10.1016/j.freeradbiomed.2021.11.019.
  • Giannerini S, Gonzalez DL, Goracci G, Danielli A. A role for circular code properties in translation. Sci Rep. 2021 Apr 28;11(1):9218. doi: 10.1038/s41598-021-87534-y.
  • Cantelli A, Piro F, Pecchini P, Di Giosia M, Danielli A, Calvaresi M. Concanavalin A-Rose Bengal bioconjugate for targeted Gram-negative antimicrobial photodynamic therapy. J Photochem Photobiol B. 2020 Mar 13;206:111852. doi: 10.1016/j.jphotobiol.2020.11185

     

Contacts