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Department of Pharmacy and Biotechnology - FABIT

Molecular Biotechnology Lab (MBT). Coordinator: Danielli

Development of biotherapeutics and biosensors based on filamentous phages and self-assembling bionanoparticles.

Areas: Drug discovery and development Industrial, plant and environmental biotechnologies Nutrition and health
Engineered phage (red) targeting epidermoid cancer cells

Research themes

  1. Engineering of phage-based targeting vectors for innovative therapeutics
  2. Phage biosensors
  3. Phage- and NP-based supplements for human and veterinary health-care

 

Visit the MBT-lab website

 

Lab Members

Alberto Danielli,  Associate Professor 

Paolo Emidio Costantini, Tenur Track Assistant Professor

Michela Nigro,  Reaserch Fellow/Post Doc

Lucia Pappagallo, PhD Student

Alena Kaltenbrunner, PhD Student

Pietro Cocco, Reaserch Fellow

Internship projects

Contact the group leader

Main publications

  • Costantini PE, Saporetti R, Iencharelli M, Flammini S, Montrone M, Sanità G, De Felice V, Mattioli EJ, Zangoli M, Ulfo L, Nigro M, Rossi T, Di Giosia M, Esposito E, Di Maria F, Tino A, Tortiglione C, Danielli A, Calvaresi M. Phage-Templated Synthesis of Targeted Photoactive 1D-Thiophene Nanoparticles. Small. 2025 Jan;21(1):e2405832. doi: 10.1002/smll.202405832.
  • Turrini E, Ulfo L, Costantini PE, Saporetti R, Di Giosia M, Nigro M, Petrosino A, Pappagallo L, Kaltenbrunner A, Cantelli A, Pellicioni V, Catanzaro E, Fimognari C, Calvaresi M, Danielli A. Molecular engineering of a spheroid-penetrating phage nanovector for photodynamic treatment of colon cancer cells. Cell Mol Life Sci. 2024 Mar 17;81(1):144. doi: 10.1007/s00018-024-05174-7.
  • Petrosino A, Saporetti R, Starinieri F, Sarti E, Ulfo L, Boselli L, Cantelli A, Morini A, Zadran SK, Zuccheri G, Pasquini Z, Di Giosia M, Prodi L, Pompa PP, Costantini PE, Calvaresi M, Danielli A. A modular phage vector platform for targeted photodynamic therapy of Gram-negative bacterial pathogens. iScience. 2023 Sep 27;26(10):108032. doi: 10.1016/j.isci.2023.108032.
  • Ulfo L, Cantelli A, Petrosino A, Costantini PE, Nigro M, Starinieri F, Turrini E, Zadran SK, Zuccheri G, Saporetti R, Di Giosia M, Danielli A, Calvaresi M. Orthogonal nanoarchitectonics of M13 phage for receptor targeted anticancer photodynamic therapy. Nanoscale. 2022 Jan 20;14(3):632-641. doi: 10.1039/d1nr06053h.
  • Cantelli A, Piro F, Pecchini P, Di Giosia M, Danielli A, Calvaresi M. Concanavalin A-Rose Bengal bioconjugate for targeted Gram-negative antimicrobial photodynamic therapy. J Photochem Photobiol B. 2020 Mar 13;206:111852. doi: 10.1016/j.jphotobiol.2020.11185

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