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Department of Pharmacy and Biotechnology - FABIT

Molecular Biotechnology Lab (MBT). Coordinator: Danielli

Development of innovative nanomedicines and biosensors based on filamentous phages and self-assembling bionanoparticles.

Areas: Drug discovery and development Industrial, plant and environmental biotechnologies Nutrition and health
Engineered phage (red) targeting epidermoid cancer cells

Research themes

  1. Engineering of phage-based targeting vectors for innovative therapeutics
  2. Phage biosensors
  3. Phage- and NP-based supplements for human and veterinary health-care

Visit the MBT-lab website

 

Lab Members

Alberto Danielli, Associate Professor (e-mail)

Paolo Emidio Costantini, Post-doctoral Researcher

Michela Nigro, Research Fellow/Post- Doc (from 1st March 2024)

Tommaso Rossi, PhD Student

Lucia Pappagallo, PhD Student

Alena Kaltenbrunner, PhD Student

Matteo Calvaresi, PA, Dept. Ciamician, UniBO

Internship projects

Contact the group leader

Main publications

  • Petrosino A, Saporetti R, Starinieri F, Sarti E, Ulfo L, Boselli L, Cantelli A, Morini A, Zadran SK, Zuccheri G, Pasquini Z, Di Giosia M, Prodi L, Pompa PP, Costantini PE, Calvaresi M, Danielli A. A modular phage vector platform for targeted photodynamic therapy of Gram-negative bacterial pathogens. iScience. 2023 Sep 27;26(10):108032. doi: 10.1016/j.isci.2023.108032.
  • Ulfo L, Cantelli A, Petrosino A, Costantini PE, Nigro M, Starinieri F, Turrini E, Zadran SK, Zuccheri G, Saporetti R, Di Giosia M, Danielli A, Calvaresi M. Orthogonal nanoarchitectonics of M13 phage for receptor targeted anticancer photodynamic therapy. Nanoscale. 2022 Jan 20;14(3):632-641. doi: 10.1039/d1nr06053h.
  • Ulfo L, Costantini PE, Di Giosia M, Danielli A, Calvaresi M. EGFR-Targeted Photodynamic Therapy. Pharmaceutics. 2022 Jan 20;14(2):241. doi: 10.3390/pharmaceutics14020241.
  • Bortot B, Apollonio M, Baj G, Andolfi L, Zupin L, Crovella S, di Giosia M, Cantelli A, Saporetti R, Ulfo L, Petrosino A, Di Lorenzo G, Romano F, Ricci G, Mongiat M, Danielli A, Calvaresi M, Biffi S. Advanced photodynamic therapy with an engineered M13 phage targeting EGFR: Mitochondrial localization and autophagy induction in ovarian cancer cell lines. Free Radic Biol Med. 2022 Feb 1;179:242-251. doi: 10.1016/j.freeradbiomed.2021.11.019.
  • Cantelli A, Piro F, Pecchini P, Di Giosia M, Danielli A, Calvaresi M. Concanavalin A-Rose Bengal bioconjugate for targeted Gram-negative antimicrobial photodynamic therapy. J Photochem Photobiol B. 2020 Mar 13;206:111852. doi: 10.1016/j.jphotobiol.2020.11185

     

Contacts

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