Neuropsychopharmacology. Coordinators: Carboni/Rimondini

The Neuropsychopharmacology group investigates the neurobiological basis of psychiatric and neurological disorders

Figure 1: Experimental design

Research themes 

1) Neurobiology and pharmacology of neurodegenerative disorders (Alzheimer’s disease, Parkinson’s disease, developmental disorders);

2) Neurobiology, pharmacology, and biomarkers of psychiatric disorders (major depressive disorder, anxiety, addiction, schizophrenia);

3) Drug discovery in neuroscience.

Lab Members  

Internship Projects 

Investigations on models of neurological and psychiatric disorders for students in the degrees of Medical Biotechnology, Pharmaceutical Biotechnologies, Farmacia, Pharmacy, CTF, Molecular and Cell Biology, Biologia della salute, Scienze Farmaceutiche Applicate.


Main Publications

  • Carboni L, El Khoury A, Beiderbeck DI, Neumann ID, Mathé AA. (2022) Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours. Eur Neuropsychopharmacol. 57:1-14.
  • Gennaccaro L, Fuchs C, Loi M, Pizzo R, Alvente S, Berteotti C, Lupori L, Sagona G, Galvani G, Gurgone A, Raspanti A, Medici G, Tassinari M, Trazzi S, Ren E, Rimondini R, Pizzorusso T, Giovanna Z, Maurizio G, Elisabetta C. (2021) Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death. Aging Dis. 12:764-785
  • Carboni L, Marchetti L, Lauria M, Gass P, Vollmayr B, Redfern A, Jones L, Razzoli M, Malki K, Begni V, Riva MA, Domenici E, Caberlotto L, Mathé AA. (2018) Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression. Neuropsychopharmacology. 43:2134-2145.
  • Carboni L, McCarthy DJ, Delafont B, Filosi M, Ivanchenko E, Ratti E, Learned SM, Alexander R, Domenici E. (2019) Biomarkers for response in major depression: comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies. Transl Psychiatry. 9:182.
  • Caberlotto L, Nguyen TP, Lauria M, Priami C, Rimondini R, Maioli S, Cedazo-Minguez A, Sita G, Morroni F, Corsi M, Carboni L. (2019) Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases. Sci Rep. 9:3965.