Il seminario si svolgerà in lingua inglese e in presenza.
ABSTRACT
Historically, histamine is widely recognized as a pivotal mediator of inflammatory responses. However, histamine has also been recognized as one of the most important neurotransmitters involved in cognitive processes. The augmentation of histamine activity produced by H3 receptor (H3R) antagonism within the cortical and limbic areas leads to a positive effect on cognition that may be useful in treating cognitive decline related to Alzheimer's disease, Lewy body dementia, schizophrenia, and other conditions. In addition, the simplicity and structurally diverse scaffolds of H3R antagonists open opportunities for modulating additional targets synergistically, thereby potentiating this procognitive effect through a multitargeting approach. In the last years, our group has made efforts towards the search for novel agents against neurodegenerative and neuroinflammatory diseases by designing multitarget ligands using the H3R antagonists’ pharmacophores as inspiration. The progress we have obtained in this endeavor will be discussed during this presentation.