Il seminario si svolgerà in presenza e in lingua inglese
ABSTRACT
Glucose is a vital source of energy for cells, and its transportation into cells is crucial for various physiological processes, including cellular respiration and metabolism. GLUT transporters, a family of membrane proteins also known as glucose transporters, facilitate the passage of glucose across cell membranes. These transporters have different affinities for glucose and exhibit different tissue distributions. The most well-known member of this family is GLUT1, which is found in various tissues and plays a fundamental role in glucose uptake, particularly in cells that have a constant need for glucose, such as red blood cells and the blood-brain barrier. Through selected examples from our work carried out using computer simulation, I will provide an overview of the current knowledge we have about transport and selectivity in this family of transporters.