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Department of Pharmacy and Biotechnology - FABIT

Cancer biology

Development and application of cell and molecular biology, genetics, biochemistry and nanotechnology to understand tumorigenesis and tumor progression

Cancer is a highly heterogeneous disease stemming from normal cells acquiring aberrant features, such as hyperproliferation, immunoevasion and deregulated cellular energetics.

The research activities in Cancer Biology employ several approaches to investigate the causes of this aberrant acquisition, using experiments and approaches both computational, genetical and molecular. Further screening of cancer cells is performed using data acquisition of biochemical, metabolic and transcriptional features. This scope aims also at understanding the action of pathogenic organisms (viruses and bacteria) with oncogenic properties and, more in general, focuses on the identification of novel anti-cancer molecular targets and innovational therapeutic strategies.

People

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Monica Baiula

Associate Professor

keywords: Integrin, Drug discovery, Inflammation, Molecular Pharmacology

Christian Bergamini

Associate Professor

keywords: Mitochondria, Mitochondrial electron transfer chain, Reactive Oxygen Species, Coenzyme Q10

Roberto Bernardoni

Assistant professor

keywords: Animal models of molecular mechanisms related to the onset and progression of childhood neuroblastoma, autism spectrum

Fabrizio Bertolazzi

PhD Student

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Elisa Bonanni

PhD Student

keywords: Bioinformatics, Computational Oncology, Cancer Biology, Machine Learning, Cancer Risk, Early Detection, Multi-Omics
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Renato Brandimarti

Assistant professor

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Concettina Cappadone

Associate Professor

keywords: magnesium, biomineralization, cancer, cell cycle, MDR
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Giovanni Capranico

Full Professor

keywords: DNA topoisomerases, R-loop and non-B DNA structures, Non-coding RNAs, Espressione genica, Transcription regulation,
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Emidio Capriotti

Associate Professor

keywords: Analysis and interpretation of cancer genome., Genome interpretation and prediction of disease-related protein
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Stefano Luciano Ciurli

Full Professor

keywords: Bioinorganic Chemistry, Biomodelling, Biomolecular NMR spectroscopy, Metallo-chaperons, Urease, X-ray absorption
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Emma Coschina

PhD Student

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Dario De Biase

Associate Professor

keywords: Molecular Pathology, Molecular alterations of solid tumors, Next Generation Sequencing, Tumors
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Anna Maria Ghelli

Associate Professor

keywords: mitochondria, Leber's Hereditary Optic Neuropathy, apoptosis, complex I, OPA1, Dominant Optic Atrophy, cancer
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Federico Manuel Giorgi

Associate Professor

keywords: Bioinformatics, Transcriptomics, Gene Networks, Plant Biology, Cancer Biology, Genomics, Biostatistics
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Laura Giusti

Associate Professor

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Luisa Iommarini

Associate Professor

keywords: mitochondria, cancer, tumor, metabolism, hypoxia, oxidative phosphorylation
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Stefano Iotti

Full Professor

keywords: fluorescent dyes, Magnesium, Biosensors, hydroxyquinoline derivatives, Synchreotron-based x-ray microscopy, magnetic

Monia Lenzi

Associate Professor

keywords: Chemoprevention, Genotoxicity, NPS, Flowcytometry

Emil Malucelli

Associate Professor

keywords: Metabolites Absolute Qunatification, Functional Imaging, MRS, Registration, Diffusion Tensor imaging, Tractography,
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Jessica Marinello

Associate Professor

keywords: Human Topoisomerases, R-loops, Non canonical DNA structures, G-quadruplex, DNA damage
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Luca Mazzei

Fixed-term Researcher in Tenure Track L. 79/2022

Laura Menotti

Associate Professor

keywords: viral vectors, oncolytic virotherapy, HER2 receptor, tumor-specific receptors, viral retargeting ad detargeting, herpes
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Giorgio Milazzo

Associate Professor

keywords: Genetics, Molecular Biology, Cancer Biology, Neuroblastoma
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Francesco Musiani

Associate Professor

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Cecilia Prata

Associate Professor

keywords: Nutraceuticals, Signal transduction, NAD(P)H oxidases, Reactive Oxygen Species (ROS), Aquaporins, Antioxidants
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Gloria Ravegnini

Senior assistant professor (fixed-term)

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Manuela Sollazzo

Fixed-term Researcher in Tenure Track L. 79/2022

keywords: cancer; metabolism; Respiratory Complex I; pro-tumorigenic signaling cascades; Drosophila melanogaster
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Roberto Tonelli

Assistant professor

keywords: Pharmaceutical Biotechnology, Preclinical Molecular Pharmacology, Oncology
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Maria Paola Turina

Assistant professor

keywords: ATP synthase, proton transport, electron tranfer, photosynthetic Reaction Center
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Barbara Zambelli

Associate Professor

keywords: intrinsically disordered proteins, metal-homeostasis, urease, nickel, protein-protein interactions
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Giampaolo Zuccheri

Associate Professor