Genomics

Development of experimental and bioinformatical methods to sequence, analyze and functionally understand prokaryotic and eukaryotic genomes

This scope studies prokaryotic and eukaryotic genomes to understand their architecture and dynamic functionality. Genomics naturally extends to the study of expressed gene transcripts (Transcriptomics) and to the active chromatin modifications (Epigenomics) to unveil the mechanisms by which genomes respond to stimuli in different histological tissues and pathological conditions. Human Genomics studies somatic mutations causally linked to cancer, germline polymorphisms linked to genetic diseases and mutations cause by the exposition to external mutagens (Toxicogenomics). In prokaryotes, the department research activities focus on the study of human pathogens and of novel bacterial species able to synthesize novel molecules with industrial and pharmaceutical applications.

People

foto della persona

Giulia Babbi

Junior assistant professor (fixed-term)

keywords: Proteomics, Database development, Protein annotation, Gene-Disease relation, Rare diseases, Machine learning, Genomics,
foto della persona

Davide Baldazzi

PhD Student

Teaching tutor

keywords: Bioinformatics, Proteomics, Machine Learning, Cancer Genomics

Roberto Bernardoni

Assistant professor

keywords: Animal models of molecular mechanisms related to the onset and progression of childhood neuroblastoma, autism spectrum
foto della persona

Martina Cappelletti

Senior assistant professor (fixed-term)

keywords: Molecular microbiology, Microbial biotechnology, Microbial genomics, Omics applied to microbiology, Enviornmental
foto della persona

Giovanni Capranico

Full Professor

keywords: DNA topoisomerases, R-loop and non-B DNA structures, Non-coding RNAs, Espressione genica, Transcription regulation,
foto della persona

Paolo Emidio Costantini

Research fellow

Teaching tutor

foto della persona

Marco Fabbrini

PhD Student

keywords: Microbiome, Metagenomics, Microbiota
foto della persona

Giorgio Gallinella

Full Professor

keywords: Parvovirus B19, Virus-cell interaction, Viral infections, Recombinant virus, Antiviral compounds
foto della persona

Federico Manuel Giorgi

Associate Professor

keywords: Bioinformatics, Transcriptomics, Gene Networks, Plant Biology, Cancer Biology, Genomics, Biostatistics

Davide Maestri

PhD Student

Research fellow

foto della persona

Daniele Mercatelli

Adjunct professor

Research fellow

Teaching tutor

keywords: Bioinformatics, Transcriptomics, Gene Networks, Genomics, Oncology, Biostatistics, Radiomics
foto della persona

Giulia Miglietta

Research fellow

Teaching tutor

keywords: DNA secondary structure, G4 quadruplex, genome instability, DNA damage
keywords: bacterial pathogenesis
foto della persona

Simone Rampelli

Junior assistant professor (fixed-term)

keywords: Microbiome, Metagenomics, Microbiota, Microbial Evolution

Patrizia Romualdi

Associate Professor

foto della persona

Marco Russo

Research fellow

keywords: Bioinformatics, DRIP-sequencng, RNA-sequencing, DNA secondary structures, G-quadrplexes, R-loop, Genome instability
foto della persona

Vincenzo Scarlato

Full Professor

keywords: TRANSCRIPTOME, PROTEIN-DNA INTERACTIONS, TRANSCRIPTIONAL REGULATION, FUNCTIONAL GENOMICS
foto della persona

Roberto Tonelli

Assistant professor

keywords: Pharmaceutical Biotechnology, Preclinical Molecular Pharmacology, Oncology
keywords: Molecular biotechnology of phages- Development of theranostic vectors- Gene expression regulation in cancer- Molecular