Cancer biology

Development and application of cell and molecular biology, genetics, biochemistry and nanotechnology to understand tumorigenesis and tumor progression

Cancer is a highly heterogeneous disease stemming from normal cells acquiring aberrant features, such as hyperproliferation, immunoevasion and deregulated cellular energetics.

The research activities in Cancer Biology employ several approaches to investigate the causes of this aberrant acquisition, using experiments and approaches both computational, genetical and molecular. Further screening of cancer cells is performed using data acquisition of biochemical, metabolic and transcriptional features. This scope aims also at understanding the action of pathogenic organisms (viruses and bacteria) with oncogenic properties and, more in general, focuses on the identification of novel anti-cancer molecular targets and innovational therapeutic strategies.

People

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Giulia Babbi

Junior assistant professor (fixed-term)

keywords: Proteomics, Database development, Protein annotation, Gene-Disease relation, Rare diseases, Machine learning, Genomics,
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Monica Baiula

Senior assistant professor (fixed-term)

D cat. - technical, scientific and data processing area

keywords: Integrin, Drug discovery, Inflammation, Molecular Pharmacology
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Federica Belluti

Associate Professor

keywords: natural products, multititarget drug discovery, design and synthesis of small molecules, antineurodegenetive small

Christian Bergamini

Associate Professor

keywords: Mitochondria, Mitochondrial electron transfer chain, Reactive Oxygen Species, Coenzyme Q10

Roberto Bernardoni

Assistant professor

keywords: Animal models of molecular mechanisms related to the onset and progression of childhood neuroblastoma, autism spectrum
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Renato Brandimarti

Assistant professor

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Natalia Calonghi

Associate Professor

keywords: EGFR, colon cancer, 9-hydroxystearic acid, lipid peroxidation, histone deacetylase, Cell signalling
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Concettina Cappadone

Assistant professor

keywords: magnesium, biomineralization, cancer, cell cycle, MDR
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Giovanni Capranico

Full Professor

keywords: DNA topoisomerases, R-loop and non-B DNA structures, Non-coding RNAs, Espressione genica, Transcription regulation,
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Emidio Capriotti

Associate Professor

keywords: Analysis and interpretation of cancer genome., Genome interpretation and prediction of disease-related protein
keywords: Bioinorganic Chemistry, Biomodelling, Biomolecular NMR spectroscopy, Metallo-chaperons, Urease, X-ray absorption
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Dario De Biase

Associate Professor

keywords: Molecular Pathology, Molecular alterations of solid tumors, Next Generation Sequencing, Tumors
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Fulvia Farabegoli

Assistant professor

keywords: EGCG, green tea, cancer, breast carcinoma, neuroblastoma, chemoprevention
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Giovanna Farruggia

Assistant professor

keywords: fluorescece spectroscopy, flow cytometry, magnesium, fluorescent dye, cell proliferation
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Diana Fiorentini

Assistant professor

keywords: Antioxidants, Lipid rafts, Aquaporins, Redox signalling, NAD(P)H oxidase, Acute myeloid leukaemia, Glucose transport,
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Anna Maria Ghelli

Associate Professor

keywords: mitochondria, Leber's Hereditary Optic Neuropathy, apoptosis, complex I, OPA1, Dominant Optic Atrophy, cancer
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Federico Manuel Giorgi

Associate Professor

keywords: Bioinformatics, Transcriptomics, Gene Networks, Plant Biology, Cancer Biology, Genomics, Biostatistics
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Silvia Granata

PhD Student

keywords: toxicology, in vitro, in vivo, pharmacology, immunology
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Luca Grillini

PhD Student

Research fellow

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Luisa Iommarini

Associate Professor

keywords: mitochondria, cancer, tumor, metabolism, hypoxia, oxidative phosphorylation
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Stefano Iotti

Full Professor

keywords: fluorescent dyes, Magnesium, Biosensors, hydroxyquinoline derivatives, Synchreotron-based x-ray microscopy, magnetic

Davide Maestri

Research fellow

PhD Student

Emil Malucelli

Associate Professor

Jessica Marinello

Senior assistant professor (fixed-term)

keywords: Human Topoisomerases, R-loops, Non canonical DNA structures, G-quadruplex, DNA damage
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Luca Mazzei

Junior assistant professor (fixed-term)

Laura Menotti

Associate Professor

keywords: viral vectors, oncolytic virotherapy, HER2 receptor, tumor-specific receptors, viral retargeting ad detargeting, herpes
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Daniele Mercatelli

Junior assistant professor (fixed-term)

keywords: Bioinformatics, Transcriptomics, Gene Networks, Genomics, Oncology, Biostatistics, Radiomics
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Stefano Miglietta

Research fellow

Teaching tutor

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Francesco Musiani

Associate Professor

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Giovanna Picone

PhD Student

Teaching tutor

keywords: Cancer, multi-drug resistence, biomineralization, bone, magnesium
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Cecilia Prata

Associate Professor

keywords: Nutraceuticals, Signal transduction, NAD(P)H oxidases, Reactive Oxygen Species (ROS), Aquaporins, Antioxidants
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Francesco Rinaldi

PhD Student

Teaching tutor

keywords: RAD51, BRCA2, BRC4
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Marco Russo

Research fellow

keywords: Bioinformatics, DRIP-sequencng, RNA-sequencing, DNA secondary structures, G-quadrplexes, R-loop, Genome instability
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Manuela Sollazzo

Research fellow

Teaching tutor

keywords: cancer; metabolism; Respiratory Complex I; pro-tumorigenic signaling cascades; Drosophila melanogaster
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Roberto Tonelli

Assistant professor

keywords: Pharmaceutical Biotechnology, Preclinical Molecular Pharmacology, Oncology
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Maria Paola Turina

Assistant professor

keywords: ATP synthase, proton transport, electron tranfer, photosynthetic Reaction Center
keywords: Molecular biotechnology of phages- Development of theranostic vectors- Gene expression regulation in cancer- Molecular
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Barbara Zambelli

Associate Professor

keywords: intrinsically disordered proteins, metal-homeostasis, urease, nickel, protein-protein interactions
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Giampaolo Zuccheri

Assistant professor