Molecular and Cellular Pharmacology. Coordinator: Spampinato

Studies focused on the discovery and characterization of novel drug targets and drugs involved in the control of inflammatory and nociceptive processes. The research can use the most advanced technologies of cellular and molecular pharmacology and genetically modified mouse models.

Research themes

1. Study of leukocyte and RGD integrins not yet adequately explored in peripheral and central inflammatory processes; pharmacological characterization of new ligands for these integrins and analysis of their contribution to modulation of inflammation and nociception in suitable experimental models.

2. Characterization of new opioid receptor ligands and analysis of the effects elicited by receptor agonists on apoptosis, proliferation and migration of tumor cells.

3. Role of the transcription factor REST on cellular apoptosis processes and expression of opioid receptors.

4. Pain Control and Stress: (opioid system, POMC, antisense strategies to control the HPA axis )

5. In vivo and in vitro studies on neurodegenarative pathology

Lab members

Coordinator: Prof. Prof. Santi Mario Spampinato

Members: Prof. Andrea Bedini;

Dr. Gabriele Campana;

Dr. Monica Baiula

Pubblicazioni significative

Bedini A, Baiula M, Vincelli G, Formaggio F, Lombardi S, Caprini M, Spampinato S. Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells. Biochem Pharmacol. 2017 Jun 2. pii: S0006-2952(17)30323-4. doi: 10.1016/j.bcp.2017.05.021.

Baiula M, Galletti P, Martelli G, Soldati R, Belvisi L, Civera M, Dattoli SD, Spampinato SM, Giacomini D. New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. J Med Chem. 2016 Nov 10;59(21):9721-9742. Epub 2016 Oct 21. PubMed PMID: 27726366.

Baiula M, Bedini A, Baldi J, Cavet ME, Govoni P, Spampinato S. Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy. Drug Des Devel Ther. 2014 Jun 10;8:745-57. doi: 10.2147/DDDT.S62659. eCollection 2014.

Baiula M, Carbonari G, Dattoli SD, Calienni M, Bedini A, Spampinato S. REST is up-regulated by epidermal growth factor in HeLa cells and inhibits apoptosis by influencing histone H3 acetylation. Biochim Biophys Acta. 2012 Aug;1823(8):1252-63. doi: 10.1016/j.bbamcr.2012.05.026.

Travaglione S, Ballan G, Fortuna A, Ferri A, Guidotti M, Campana G, Fiorentini C, Loizzo S. CNF1 Enhances Brain Energy Content and Counteracts Spontaneous Epileptiform Phenomena in Aged DBA/2J Mice. PLoS One. 2015 Oct 12;10(10):e0140495. doi: 10.1371/journal.pone.0140495. eCollection 2015.