Molecular biology and applied genetics. Coordinator: Ambrosetti

To study transcription factors and retrotransposons as regulators of gene expression

Research themes

Transcription factors and retrotransposons in the regulation of gene expression and their role in lung cancer.

Study of the effects of electromagnetic fields on the epigenome within the GOLIAT project (5G expOsure, causaL effects, and rIsk perception through citizen engAgemenT, HORIZON-HLTH-2021-ENVHLTH-02).

Lab Members

Davide Carlo Ambrosetti, Associate Professor

Brunella Del Re, Senior Assistant Professor

Valentina Sancisi (IRCCS, Reggio Emilia) 

Internship projects

- Cloning of gRNA for CRISP/Cas9 mediated knock out of target genes of lung tumor cells

- Role of the transcription factor Sox 5 in melanoma

- Activity of LINE-1 elements in cultured cells treated with chemical or physical agents

Main publications

  • Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields. Giorgi G, Del Re B. Cell Tissue Res. 2021 Oct;386(1):1-15. doi: 10.1007/s00441-021-03489-6.  
  • Long INterspersed element-1 mobility as a sensor of environmental stresses. Del Re B, Giorgi G.Environ Mol Mutagen. 2020 Apr;61(4):465-493. doi: 10.1002/em.22366. 
  • An integrative functional genomics approach reveals EGLN1 as a novel therapeutic target in KRAS mutated lung adenocarcinoma. Reggiani F, et al. Mol Cancer. 2021 Apr 6;20(1):63. doi: 10.1186/s12943-021-01357-z.  
  • The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells.  Gobbi G, et al. Oncogene. 2019 Oct;38(42):6801-6817. doi: 10.1038/s41388-019-0924-1.