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Department of Pharmacy and Biotechnology - FABIT

Cancer genetics. Coordinator: de Biase

The group carries out its research in the field of solid tumors, whose molecular characteristics are analyzed in ex vivo samples using "high-throughput" methods, to search for new diagnostic, prognostic, or predictive biomarkers

Areas: Cancer biology

Research themes

1) Molecular characterization of other solid tumors.

Search for diagnostic / prognostic / predictive markers for the characterization of the following solid tumors: thyroid neoplasia, brain tumors, gynecological tuors, breast cancers, colorectal cancers, pancreatic cancers, melanomas, lung cancers, endocrine cancers, hepatocarcinomas;

2) Development of molecular analysis methods for solid tumors.

Development of laboratory-developed panels for massive parallel sequencing of solid tumors.

Lab members

Dario de Biase, Associate Professor (e-mail)

Emanuela Mensà, Research Fellow

Thais Maloberti, PhD Student DIMEC (tutor Prof. Giovanni Tallini)

Internship projects

PhD programme in “Cellular and molecular biology ” (Research Area: Molecular characterization of solid tumors). 

https://phd.unibo.it/cellular-molecular-biology/en

 

First and second cycle degrees: Characterization of solid tumors: Dario de Biase. 

https://www.unibo.it/sitoweb/dario.debiase/didattica?tab=tesi

Main publications

  • Next-Generation Sequencing Panel for 1p/19q Codeletion and IDH1-IDH2 Mutational Analysis Uncovers Mistaken Overdiagnoses of 1p/19q Codeletion by FISH. Journal of Molecular Diagnostics, 2021, 23(9):1185-1194. doi: 10.1016/j.jmoldx.2021.06.004
  • ARID1A and CTNNB1/β-catenin molecular status affects the clinicopathologic features and prognosis of endometrial carcinoma: Implications for an improved surrogate molecular classification. Cancers, 2021, 13(5): 1-22. https://www.mdpi.com/2072-6694/13/5/950/htm
  • MiR-196B-5P and miR-200B-3P are differentially expressed in medulloblastomas of adults and children. Diagnostics, 2021, 10(51). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277606/
  • Molecular diagnostic of solid tumor using a next generation sequencing custom-designed multi-gene panel. Diagnostics, 2020, 10(4), 250. https://www.mdpi.com/2075-4418/10/4/250/htm
  • Long-term survivors of pancreatic adenocarcinoma show low rates of genetic alterations in KRAS, TP53 and SMAD4. Cancer biomarkers, 2018, 21(2):323-334. doi: 10.3233/CBM-170464

 

Contacts