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Dipartimento di Farmacia e Biotecnologie - FABIT

Seminario Epigenetic switching as regulator of pathogenicity in Porphyromonas

20 luglio 2026

Prof.ssa Karolin Hijazi, Institute of Dentistry - University of Aberdeen, Scotland UK (ospite del Prof. M.R. Oggioni)

locandina dei seminari del FaBiT: collage di immagini scientifiche con cellule, molecole e farmaci per rappresentare i principali ambiti di ricerca
  • 12:00 - 13:00
  • In presenza : AULA SPAMPINATO, UE5 – Via Gobetti 87, Bologna
  • Salute, Scienza e tecnologia In inglese

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Ingresso libero

Programma

Porphyromonas gingivalis is a highly adaptable oral Gram-negative linked to both periodontal disease and a range of systemic disorders. But what drives its remarkable ability to switch from harmless colonizer to pathogen? This presentation reveals the first evidence of a phase-variable DNA methylation system in P. gingivalis. Discover how reversible epigenetic changes generate distinct bacterial subpopulations with unique virulence profiles in P. gingivalis and how genome-wide methylation reshapes gene expression and bacterial behaviour. Explore the impact of these epigenetic states on host cell invasion, immune evasion, and pathogenic potential. Combining methylomics, transcriptomics, and functional assays, this work uncovers a previously unrecognized regulatory mechanism. These findings redefine our understanding of bacterial adaptation and virulence in P. gingivalis. Join us to discover how epigenetics is transforming our view of one of the oral microbiome's most important pathogens.

Chi interverrà

  • Karolin Hijazi

    Professoressa, Institute of Dentistry - University of Aberdeen, Scotland UK
    Professor Karolin Hijazi, Clinical Chair at the University of Aberdeen (Aberdeen, Scotland), is a member of the Infection & Immunity Programme of the Institute of Medical Sciences and leads the Microbial Diseases Research Group at the Institute of Dentistry. The research work of her laboratory includes both clinical aspects and the molecular study of microbe-host interactions. Recent research focuses on the impact of cutaneous disinfectants on the prevalence of MRSA and MRSE (Sharaf et al., Lancet Microbe. 2025;6(8):101118. doi: 10.1016/j.lanmic.2025.101118) and the relevance of epigenetic gene regulation in the oral pathogen Porphyromonas gingivalis (Sharaf et al., FEMS Microbiology Rev. 2026;50:fuag014. doi: 10.1093/femsre/fuag014).

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